Delayed axonal degeneration in slow Wallerian degeneration mutant mice detected using diffusion tensor imaging
نویسندگان
چکیده
منابع مشابه
Wallerian degeneration after spinal cord lesions in cats detected with diffusion tensor imaging
One goal of in vivo neuroimaging is the detection of neurodegenerative processes and anatomical reorganizations after spinal cord (SC) injury. Non-invasive examination of white matter fibers in the living SC can be conducted using magnetic resonance diffusion-weighted imaging. However, this technique is challenging at the spinal level due to the small cross-sectional size of the cord and the pr...
متن کاملThe slow Wallerian degeneration gene, WldS, inhibits axonal spheroid pathology in gracile axonal dystrophy mice.
Axonal dystrophy is the hallmark of axon pathology in many neurodegenerative disorders of the CNS, including Alzheimer's disease, Parkinson's disease and stroke. Axons can also form larger swellings, or spheroids, as in multiple sclerosis and traumatic brain injury. Some spheroids are terminal endbulbs of axon stumps, but swellings may also occur on unbroken axons and their role in axon loss re...
متن کاملThe slow Wallerian degeneration gene, Wld, inhibits axonal spheroid pathology in gracile axonal dystrophy mice
Correspondence: Dr Michael Coleman, The Babraham Institute, Babraham, Cambridge CB2 4AT, UK E-mail: [email protected] *W. Mi and B. Beirowski contributed equally to this work ZMMK and Institute for Genetics and Department of Anatomy I, University of Cologne, Cologne, Germany, Division of Neuroscience, University of Edinburgh, Edinburgh, The Babraham Institute, Babraham, Cambridge, UK,...
متن کاملDiffusion tensor imaging in hypertrophic olivary degeneration.
SUMMARY We report DTI and fiber tractography findings in a case of hypertrophic olivary degeneration. A 51-year-old man presented with an abnormal gait and visual difficulties. MR imaging showed enlargement of the right medullary olive and a vascular lesion in the right pontine tegmentum. Fiber tractography showed decreased volume of the right central tegmental tract, supporting a diagnosis of ...
متن کاملWallerian degeneration in the optic radiation after temporal lobectomy demonstrated in vivo with diffusion tensor imaging.
PURPOSE Diffusion tensor imaging allows the quantitative assessment of the microstructural organization of tracts in vivo (MR tractography). We used the new technique of MR tractography to demonstrate the effects of temporal lobectomy on the optic radiation. METHODS Spatially normalised maps encoding magnitude of the bias (anisotropy) of diffusion of three patients with temporal lobe resectio...
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ژورنال
عنوان ژورنال: Neuroscience
سال: 2011
ISSN: 0306-4522
DOI: 10.1016/j.neuroscience.2011.09.042